KSPM
Search
- Page Path
- HOME > Search
- Corrigendum: The authors found errors in our published article: Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
- Ho-Jin Kang, Eun-Jeong Kim, Byoung-Gwon Kim, Chang-Hun You, Sang-Yong Lee, Dong-Il Kim, Young-Seoub Hong
- J Prev Med Public Health. 2012;45(5):333-333. Published online September 28, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.5.333
- Corrects: J Prev Med Public Health 2012;45(4):251
- 5,411 View
- 50 Download
-
PDF -
SummaryOriginal Article
- Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
- Ho-Jin Kang, Eun-Jeong Kim, Byoung-Gwon Kim, Chang-Hun You, Sang-Yong Lee, Dong-Il Kim, Young-Seoub Hong
- J Prev Med Public Health. 2012;45(4):251-258. Published online July 31, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.4.251
- Correction in: J Prev Med Public Health 2012;45(5):333
- 9,271 View
- 69 Download
- 11 Crossref
-
Abstract
PDF Objectives The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients.
Methods Hypermethylation profiles of nine genes (RASSF1, APC, p16INK4a, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction.
Results Nine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of p16INK4a and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, E-cadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2.
Conclusions This study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.
-
Summary
Citations
Citations to this article as recorded by
- Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing
Go Asano, Katsuyuki Miyabe, Hiroyuki Kato, Michihiro Yoshida, Takeshi Sawada, Yasuyuki Okamoto, Hidenori Sahashi, Naoki Atsuta, Kenta Kachi, Akihisa Kato, Naruomi Jinno, Makoto Natsume, Yasuki Hori, Itaru Naitoh, Kazuki Hayashi, Yoichi Matsuo, Satoru Taka
Scientific Reports.2022;[Epub] CrossRef - Potential of RASSF1A promoter methylation as a biomarker for colorectal cancer: Meta-analysis and TCGA analysis
Fei Hu, Li Chen, Ming-Yu Bi, Ling Zheng, Ji-Xiang He, Ying-Ze Huang, Yu Zhang, Xue-Lian Zhang, Qiang Guo, Ying Luo, Wen-Ru Tang, Miao-Miao Sheng
Pathology - Research and Practice.2020; 216(8): 153009. CrossRef KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway
Yi Song, Huiping Yuan, Jia Wang, Yuhe Wu, Yuhong Xiao, Shengxun Mao
Cancer Management and Research.2020; Volume 12: 3981. CrossRef- RHBDF1 regulates APC-mediated stimulation of the epithelial-to-mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/β-catenin signalling pathway
Huiping Yuan, Ran Wei, Yuhong Xiao, Yi Song, Jia Wang, Huihuan Yu, Ting Fang, Wei Xu, Shengxun Mao
Experimental Cell Research.2018; 368(1): 24. CrossRef - Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Delo
Clinical Epigenetics.2018;[Epub] CrossRef - A novel discriminating colorectal cancer model for differentiating normal and tumor tissues
Xiaohui Sun, Yiping Tian, Qianqian Zheng, Ruizhi Zheng, Aifen Lin, Tianhui Chen, Yimin Zhu, Maode Lai
Epigenomics.2018; 10(11): 1463. CrossRef - APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review
Tie-Jun Liang, Hong-Xu Wang, Yan-Yan Zheng, Ying-Qing Cao, Xiaoyu Wu, Xin Zhou, Shu-Xiao Dong
Oncotarget.2017; 8(28): 46468. CrossRef - RETRACTED ARTICLE: Aberrant promoter methylation of RASSF1A gene may be correlated with colorectal carcinogenesis: a meta-analysis
He-Ling Wang, Yu Zhang, Peng Liu, Ping-Yi Zhou
Molecular Biology Reports.2014; 41(6): 3991. CrossRef - Role of CDH1 Promoter Methylation in Colorectal Carcinogenesis: A Meta-Analysis
Yu-Xi Li, Yao Lu, Chun-Yu Li, Peng Yuan, Shu-Sen Lin
DNA and Cell Biology.2014; 33(7): 455. CrossRef - Retracted: Promoter Methylation of theRASSF1AGene may Contribute to Colorectal Cancer Susceptibility: A Meta-Analysis of Cohort Studies
He-Ling Wang, Peng Liu, Ping-Yi Zhou, Yu Zhang
Annals of Human Genetics.2014; 78(3): 208. CrossRef - Hypermethylation ofTWIST1andNID2in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients
Zeynep Yegin, Sezgin Gunes, Recep Buyukalpelli
DNA and Cell Biology.2013; 32(7): 386. CrossRef
First
Prev
